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When signi cant changes to established test speci cations occur under the accelerated storage condition, testing at the intermediate storage condition for 12 months with sampling at time 0, 6, 9, and 12 is recommended Drug Products Packaged in Impermeable Containers For drug products packaged in impermeable containers that provide a permanent barrier, moisture or solvent loss is not a concern and for such products stability studies can be conducted under any controlled or ambient humidity conditions Drug Products Packaged in Semipermeable Containers Stability studies for aqueous-based drug products packaged in semipermeable containers (containers that allow the passage of solvent, usually water, while preventing solute loss) should be conducted under conditions of low relative humidity and temperatures speci ed in Table 2 Stability attributes such as potential water loss and physical, chemical, biological, and microbiological stability should be evaluated.

These arrays contain information on three books by Steinbeck. You can see that array_multisort() has sorted all the arrays by author in ascending order as before. However, it has also sorted the three Steinbeck books East of Eden, Of Mice and Men, and The Grapes of Wrath into ascending order. You can also use array_multisort() to sort multidimensional arrays. This works in much the same way as for multiple arrays, except that you only pass in one array. The function then sorts the array by the first element of each nested array, then by the second element of each nested array, and so on. The order of the elements in the nested array is untouched. The following code illustrates how array_multisort() sorts a two-dimensional array. Figure 6-6 shows the output from the script.

If long-term storage studies are conducted at 25 C 2 C, 40% RH 5% RH and a signi cant change other than water loss occurs during the six months testing at the accelerated storage condition (40 C 2 C, 75% RH 5% RH), testing for established stability speci cations at the intermediate storage condition (30 C 2 C, 65% RH 5% RH) should be conducted to evaluate the effect of 30 C (Table 2) While a signi cant change in water loss (5% water loss from initial value) alone under accelerated storage conditions need not prompt testing of samples under the intermediate storage condition, water loss through the proposed shelf life should be monitored to ensure that the drug product has no signi cant water loss during longterm storage at 25 C 2 C, 40% RH 5% RH..

Cytidine deaminase (CDA) removes an amino group from cytidine to form uridine. This is a key target in stopping rapidly dividing cells (e.g. bacteria, cancer cells) meeting their requirements for new DNA. The enzyme is a dimer containing a single active site per subunit and requires a Zn atom at each site for addition of water to cytidine. Analogues of cytidine lacking NH2 bind tightly to CDA and are thought to be transition state analogues. One such analogue, 5- uoro3, 4-dihydrouridine (FDHU) is formed by addition of water to an inhibitor of the enzyme, 5- uoropyrimidine-2-one ribonucleoside (FZeb), catalyzed by CDA:

Many Palm and PocketPC devices have built-in Bluetooth capabilities. They are in fact ideal applications for Bluetooth. We don t cover using Bluetooth and PDAs in this chapter, however. For information on this topic, see 13.

3. Set the authentication and encryption methods. 4. Create a strong WEP or WPA-PSK key. 5. Store the settings you just created into an XML file on a Universal Serial Bus flash drive, as shown in Figure 20-4.

Figure B-5

The key to XFire Web service consumer creation is a class called XFireClientFactoryBean. This class makes the use of generated stub code a breeze. In fact, you can configure a Web service consumer declaratively in Spring writing very little additional code. Once configured in Spring, the XFireClientFactoryBean automatically creates Web service proxies based on the specified configuration. All you need to specify is the service class and the URL location for the service.

You can attach rendered images that you ve saved as PCX, JPG, JPEG, PNG, TIF, TGA, or BMP files. A great way to do this is to create a floating viewport in paper space for the rendered image, letting your clients see not only the regular drawing, but also the rendered result on one sheet of paper. (Figure 25-24 in 25 was created this way.) Remember that you can plot shaded and rendered images. See 17 for details.